Research

Research

Dr Vyjayanthi researched on  “Cellular and Molecular markers of Oocyte quality” under the supervision of Dr Helen Picton, Professor and Head of Division for Reproduction & Early development, Leeds University, UK.

The research included a study, to determine whether any significant differences in the amino acid turnover exist between developmentally competent and arrested oocytes on in vitro maturation (IVM) over a period of 24 hours. A further aim was to determine whether any significant differences exist between oocytes obtained from PCOS and non-PCOS patients.

research

Oocytes, which progressed in vitro to MII, exhibited amino acid patterns different from those, which arrested. Oocytes from PCOS patients showed a different amino acid turnover as opposed to non-PCOS patients. The data suggested a link between amino acid metabolism and oocyte quality.

She has also been involved in several Research projects in the Reproductive Medicine unit in Leeds.

  • Birth weight study – This is an observational study to investigate whether the birth weight of women affects their response to stimulation during IVF treatment.
  • A phase 2 randomised trial to investigate the dose-response relationship of a single injection of long acting FSH to initiate multiple follicular growth in IVF cycles.
  • A prospective randomised study comparing Nourish (preconception conditioning programme) with placebo in couples undergoing IVF treatment.
  • RCT of Menopur versus Gonal-F in the management of anovulatory infertility.
  • A prospective randomised study of the optimal timing for the administration of HCG in women undergoing IVF in a GnRH antagonist cycle.

Publications By Dr Vyjayanthi

1. MCQ’S & EMQ”S in surgery: A Bailey & Love Revision Guide, Second Edition 2015, Chapter 80-Gynaecology, S.Vyjayanthi & Pranathi Reddy, pages 767-775.
2. Nahar R, Rangarajan A, S.Vyjayanthi, Bhusanam K, Genetic evaluation in infertility: case of infertile couple with deletion and duplication of chromosome 9q12, Journal of Medical and Scientific Research. March 2015.
3. Hemmings KE, Maruthini D, Vyjayanthi S, Hogg JE, Balen AH, Campbell BK, Leese HJ, Picton HM, Amino acid turnover by human oocytes is influenced by gamete developmental competence, patient characteristics and gonadotrophin treatment. Human Reproduction 2013, April: 28(4); 1031-44.
4. B. Guruwadayarhalli, S.E.Jones, S.Vyjayanthi, Hysteroscopy in the diagnosis of postmenopausal bleeding, Menopause International (2007); 13: 07-20.
5. S.E.Jones, S.Vyjayanthi, B.Guruwadayarhalli, Chapter 5-Treating menstrual disturbance including pelvic pain (Excluding PCOS) –Pages 39-59. Obesity and Reproductive Health-RCOG Press 978-1-904752-39-4.
6. S.E.Jones, B.Guruwadayarhalli, S.Vyjayanthi; Surgical and interventional management of abnormal uterine bleeding, Gynaecology Forum ; 2007, 12 (2), 23-26.
7. S.Vyjayanthi, J.Glanville, E.Yasmin &A.H.Balen. Modern trends in ovulation induction Human Fertility (Camb).2007 Jun; 10(2): 117-121.
8. S. Vyjayanthi, T.Tang, M.Deivanayagam, A.Fattah, N.Bardis, A.H.Balen. “Elective cryopreservation of embryos at the pronucleate stage in women at risk of ovarian hyperstimulation syndrome may affect the overall pregnancy rate”. Fertility and Sterility 2006 Dec; 86 (6): 1773-5.
9. S.Vyjayanthi, C.R.Kingsland, R.Dunham &A.H.Balen.”National survey of current practice in assessing tubal patency in the U.K”, Human Fertility (2004) Vol 7 No4 pages-267-271.
10. M.Zachariah, S.Vyjayanthi, S.Bell-Thomas. “Thrombosis of umbilical vein varix: A Case Report. Journal of Obstetrics and Gynaecology (2004) Vol.24, No.4.
11. S. Vyjayanthi, A.J.Dawson , S.Bell-Thomas, ER.Barnor “Caesarean Section Rates: comparing the results of the National Sentinel Audit with local audit. All Wales Perinatal Survey and Confidential Enquiry into Stillbirths and Deaths in Infancy, Annual report, 2002 (November 2003) Pp 35-38. ISBN : 09525207 4 5 .
12. S. Vyjayanthi, A. Devi, S. Bell-Thomas. “ Vaginal Birth after Caesarean Section (VBAC) and Maternal choice: Our Experience”, Wales Office of Research & Development for Health & Social Care (WORD) Website, February 2003.
13. S. Vyjayanthi, N. Piskorowskyj. Follow up study of patients referred for Colposcopy with high grade cytology & subsequent negative histology, Wales Office of Research & Development for Health & Social Care (WORD) Website, February 2003.
14. S. Vyjayanthi , N.Piskorowskyj. Medical termination of pregnancy at 9-12 weeks of gestation. Journal of Obstetrics and Gynaecology (2002) Vol.22, No.6, 669-671.
15. S. Vyjayanthi, U.Rajesh, T.H.Bloomfield Haemoperitoneum due to placenta percreta in the third trimester mimicking placental abruption. Journal of Obstetrics and Gynaecology (2002).Vol.22, No.6, 690.
16. U.Rajesh, S. Vyjayanthi, N.Piskorowskyj. Silent uterine rupture following second trimester medical termination of pregnancy in a patient with three previous sections and an artificial urinary sphincter. Journal of Obstetrics and Gynaecology (2002) Vol.22, No.6, 687.
17. S. Vyjayanthi, P.J.Banfield and P.G.Toon. Elevated Ca-125 levels and endometriosis. Journal of Obstetrics and Gynaecology (2001) Vol.21, No.5, 545.

Presentations to Learned Societies where Dr. Vyjayanthi is a Guest Speaker India

  1. S.Vyjayanthi, Ultrasound only monitoring for IVF cycles, 23rd Annual Congress of Indian Society of Assisted Reproduction, 19-22nd April 2018, Kolkata.
  1. S.Vyjayanthi, Panel discussion-How do we enhance success rates in IVF? KISAR Annual Conference-Gaining momentum in ART, 1st April 2017, Bangalore.
  2. S.Vyjayanthi, Personalized Luteal Support, KISAR Annual Conference-Gaining Momentum in ART, 2nd April 2017. Bangalore.
  3. S.Vyjayanthi, Panel Discussion-Fresh versus Frozen Embryo Transfer, 22nd Annual Congress of ISAR 2017, 21st April 2017, Delhi.
  4. S.Vyjayanthi, Ovulation Induction in PCOS: current options, CME Programme , 28th April 2017, Hyderabad.
  5. S.Vyjayanthi, Ovulation Induction-Does Letrozole add value? OGSH CME on Neutraceuticals in Pregnancy and Lactation and a comeback in OI, 28TH June 2017, Hyderabad.
  6. Juhee P &S.Vyjayanthi, Outpatient Hysteroscopy in subfertile patients-An Observational Study, FOGSI FIGO2017 International Congress on Clinical challenges in OBGYN, 6TH August 2017.
  7. S.Vyjayanthi, Get Smart-Know your instruments needed for OPU, Association of clinical Embryologists Annual Conference, September 2017.
  8. S.Vyjayanthi, Debate: Multiple Uterine Fibroids-Surgical versus Medical management-Dr Prakash Trivedi (Surgical)VS Dr.Vyjayanthi (Medical), DR Sulochana Gunasheela Memorial Conference, 13-15th October 2017, Bangalore.
  1. S.Vyjayanthi, Evaluation of the infertile couple, ISOPARB Hyderabad Chapter, 21st January 2016, Hyderabad.
  2. S.Vyjayanthi, PCOS Management-Newer Trends, OGSH, 17th February 2016, Hyderabad.
  3. S.Vyjayanthi, Partnering in IVF centres, ICOG-FOGSI National Conference on Fertility Regulation and Women’s Health, 27th August 2016, Hyderabad.
  4. S.Vyjayanthi, Why, How & When of PGS-Preimplantation Genetic Screening: Current Practices, CME programme , Fernandez Hospital, 3rd October 2016, Hyderabad.
  5. S .Vyjayanthi, Treating Poor Responders, 8th Annual Conference of ISOPARB Hyderabad Chapter, Maatrika 2016, 3-4rth December 2016, Hyderabad.
  6. S.Vyjayanthi, Current concepts of oocyte banking, embryo donation and surrogacy, Indian Menopause Society, Hyderabad Chapter, 17TH December 2016, Hyderabad.
  1. S.Vyjayanthi, ART in perimenopause and ethics, IMS Hyderabad Zonal Conference, 18th April 2015, Hyderabad.
  2. S.Vyjayanthi, Symposium on multiple pregnancy-forming protocols-Luteal phase support in ART pregnancies, Fernandez hospital, 23rd January 2015, Hyderabad.
  3. S.Vyjayanthi, Ovarian reserve-how to assess?, Maatrika 2014, 9th November 2014, Hyderabad.
  4. S.Vyjayanthi, CME-PCOD an update, OGSH Hyderabad, 13th August 2014, Hyderabad.
  5. S.Vyjayanthi, Endocrinology of early pregnancy, IGNITE, Phase 1-CME on Reproductive Endocrinology, organised by ICOG in association with OGSH, 23rd April, 2014, Hyderabad.
  6. S.Vyjayanthi, Panel discussion –clinical scenarios on tubal factors, RCOG world congress 2014, Workshop: Trouble shooting in infertility, 27th March 2014, Hyderabad.
  7. S.Vyjayanthi, Meet the experts-Q&A session, RCOG world congress 2014, Workshop: Trouble shooting in infertility, 27th March 2014, Hyderabad.
  8. S. Vyjayanthi, Ethics in fertility management, DR.Santabai Satwalker Oration, IMA meeting, 29th October 2013, Hyderabad.
  9. S.Vyjayanthi, AMH or Antral follicle count to determine ovarian reserve? Maatrika 2013, ISOPARB Hyderabad chapter, 20th October 2013, Hyderabad.
  10. S.Vyjayanthi, Panel discussion-Infertility with pathology-case scenarios, OGSH-CME on IUI, OGSH in coordination with Infertility committee of FOGSI, 19th June 2013, Hyderabad.
  11. S.Vyjayanthi, Chair-Male subfertility-ISOPARB , 13th June 2013, Hyderabad.
  12. S.Vyjayanthi, Panel discussion-Situational analysis in infertility and endoscpic solutions-OI to IUI (workshop)-15th APCOG 2013, 20th April 2013, Hyderabad.
  13. S.Vyjayanthi, Luteal phase defect, Vizag Obs and Gynaecological Society Meeting, 5th April 2013.
  14. S.Vyjayanthi, Moderator-Panel discussion on Is progesterone now the most important drug in obstetrics? Vizag Obstetrics and Gynaecological Society Meeting, 5th April 2013.
  15. S.Vyjayanthi, Panel discussion-Endometriomas and ART-International conference on infertility-2012, organised by FOGSI and OGSH , Hyderabad, 17th December 2012.
  16. S.Vyjayanthi, Diminished ovarian reserve in infertility, MAATRIKA 2012, 3rd November 2012, Hyderabad.
  17. S.Vyjayanthi, Unexplained infertility-evidence based management, Advances 2012, 13th Annual International Congress in obstetrics, gynaecology and Reproductive medicine, 22nd September 2012, Trivandrum.
  18. S.Vyjayanthi, Hyperprolactinaemia and anovulation, Advances 2012, 13th Annual International Congress in obstetrics, gynaecology and Reproductive medicine, 22nd September 2012, Trivandrum.
  19. S.Vyjayanthi, IVF in women with medical disorders-when to say no?, Obstetric Medicine Update-14th Annual CME, Society of Obstetric Medicine, India, 8th September 2012, Hyderabad.
  20. S.Vyjayanthi, Selecting the best sperm-ICSI or IMSI? APCOG 2012, 21st July 2012, Hyderabad.
  21. S.Vyjayanthi, Non invasive assessment of embryo-role of metabolomics, 17TH National Conference of ISAR (Indian Society of Assisted Reproduction) 2012, 4rth March 2012,Raipur.
  22. S.Vyjayanthi, Non-invasive assessment of embryo-Does it improve embryo selection and is it cost effective in Indian scenario?, Optimising ART outcome-through individualised protocols, Hosted by KISAR-ISMAAR, 5th February 2012, Bangalore.
  23. S.Vyjayanthi, Lab aspects of ART-Meet the experts Breakfast session, Optimising ART outcome-through individualised protocols, Hosted by KISAR-ISMAAR, 5th February 2012, Bangalore.
  24. S.Vyjayanthi, Infertility-Recent trends in management, IMSACON-2011, 5th November 2011, Hyderabad.
  25. S.Vyjayanthi, Role of insulin sensitising agents in ovulation induction –The evidence, Fertility Congress, 2011, 26th June 2011. Hyderabad.
  26. S.Vyjayanthi, Panel discussion-“Endometriosis and infertility”, ISOPARB meeting, 21st July,2011, Hyderabad.
  27. S.Vyjayanthi, “Panel discussion-Management of unexplained infertility”, 16TH National Conference of ISAR (Indian Society of Assisted Reproduction) 2011, Agra.
  28. S.Vyjayanthi, Aromatase inhibitors-An alternative to clomiphene citrate, AICOG-2011, 5th January 2011, Hyderabad.
  29. S.Vyjayanthi, IUI-An update, Regional CME Programme, 22nd August 2010, Hyderabad.
  30. S.Vyjayanthi, “Panel Discussion-Recurrent Implantation failure”.15th National Congress of ISAR, 11th April, 2010, Cochin.
  31. S.Vyjayanthi, Day 3 versus Day 5 transfers in repeated IVF failures, Ovary unravelled, December 2009, Mumbai.
  32. S.Vyjayanthi, Management of Infertility-Facts, Realities and Evidence, APCOG, July 2009, Rajmundry.
  33. S.Vyjayanthi, Management of Anovulatory infertility, Regional CME Programme, March 18th 2009, Hyderabad.
  1. S.Vyjayanthi, K.E.Hemmings, J.E.Hogg, A.H.Balen & H.Picton.”Non-invasive measurement of amino acid turnover by individual human oocytes in spent culture media”, British Fertility Society Annual Meeting, 12 April 2007.
  2. Bardis N, Hamzeh R, Tang T, Yasmin E, Vyjayanthi S, Balen AH. Does low birth weight affect the ovarian reserve and the response to IVF treatment?. 22nd Annual meeting of ESHRE. 18-21 June 2006.
  3. E.Yasmin, R.Hamzeh, S.Vyjayanthi, J.Smith, A.H. Balen. Sonohysterography for evaluation of the endometrial cavity in women undergoing fertility treatment. The annual Congress of the International College of Gynaecological Imaging. 15-17 December 2005.
  4. S.Vyjayanthi, C.R.Kingsland, R.Dunham &A.H.Balen.”National survey of current practice in assessing tubal patency in the U.K”, Organon Nurses Conference. June 2004.
  5. S. Vyjayanthi, T.Tang, M.Deivanayagam, A.Fattah, N.Bardis, A.H.Balen. “Does elective cryopreservation of embryos at pronucleate stage(freeze-all cycles) in women at risk of ovarian hyperstimulation syndrome(OHSS) affect the overall pregnancy rates?”, British Fertility Society Annual Meeting, 30 March-2 April 2004.
  6. S. Vyjayanthi, C.R.Kingsland, A.H.Balen. “National Survey of current practice in assessing tubal patency in the UK”, Joint ACE/BFS-British Fertility Society Meeting, 5-6 January 2004.
  7. S. Vyjayanthi, S.Basu, G.Jose, N.Hammadieh, J.Evans. – Selective follicular reduction in superovulated IUI cycle-Does it affect pregnancy outcome? A Tertiary centre experience. International Congress on infertility, Bombay, India., 14-16 November 2003.
  8. S. Vyjayanthi, S.Bell-Thomas, E.R.Barnor, A.J.Dawson. “Caesarean Section Rates: comparing the accuracy of the National Sentinel Audit with local audit. India Day, Royal College of Obstetricians and Gynaecologists, 4 July 2003.
  9. S. Vyjayanthi, N.Piskorowskyj “A Follow up study of patients with high grade cytology on smear and negative colposcopy”, The British Society for Colposcopy and Cervical Pathology-BSCCP, Annual Scientific Meeting, 10-12 April 2003, Manchester .
  10. S. Vyjayanthi, S.Bell-Thomas, E.R.Barnor, A.J.Dawson. “Caesarean Section Rates: comparing the accuracy of the National Sentinel Audit with local audit. Welsh Obstetric and Gynaecology Society Meeting, 4 April 2003 .
  11. M.Zachariah, S.Vyjayanthi, S.Bell-Thomas. “Thrombosis of umbilical vein varix: Case Report. Welsh Obstetric and Gynaecology Society Meeting, 4 April 2003.
  12. S. Vyjayanthi, A. Devi, S. Bell-Thomas. “ Vaginal birth after Caesarean Section (VBAC) and Maternal choice: Our Experience”, Conversazione 2002 (Peer Reviewed Section), Health & Social care Exhibition, University of Wales, Swansea, 12 December 2002.
  13. S. Vyjayanthi, N.Piskorowskyj “A Follow up study of patients referred for Colposcopy with high grade cytology on smear and subsequent negative histology”, Conversazione 2002 (Peer Reviewed Section), Health & Social care Exhibition, University of Wales, Swansea, 12 December 2002.
  14. S. Vyjayanthi, N.Piskorowskyj “Audit on Medical Termination of Pregnancy”, Conversazione 2002, Health & Social care Exhibition, University of Wales, Swansea, 12 December 2002.
  15. S. Vyjayanthi, N. Piskorowskyj – A follow up study of patients referred for Colposcopy with high grade cytology & subsequent negative histology. Fourth All Wales Cervical Screening Conference, Newtown, 2 December 2002
  16. S. Vyjayanthi, N.Piskorowskyj “A Follow up study of patients referred for colposcopy with high grade cytology on smear and subsequent negative histology”, Welsh Obstetric &Gynaecological Society Meeting, 4 October 2002.
  17. Vyjayanthi, A O’Leary, P.J.Banfield “Haemoperitoneum due to pelvic endometriosis in the third trimester in a twin pregnancy mimicking placental abruption”, Welsh Obstetric &Gynaecological Society Meeting, 4 October 2002.
  18. S. Vyjayanthi, N.Piskorowskyj “Medical termination of pregnancy at 9-12 weeks of gestation-, Welsh Obstetric &Gynaecological Society Meeting, 26 April 2002.
  19. S. Vyjayanthi, U.Rajesh, T.H.Bloomfield “Haemoperitoneum due to placenta percreta in the third trimester mimicking placental abruption”, Welsh Obstetric &Gynaecological Society Meeting, 26 April 2002.
  20. S. Vyjayanthi, U.Rajesh, N.Piskorowskyj “Silent uterine rupture following second trimester medical termination of pregnancy in a patient with three previous sections and an artificial urinary sphincter” Welsh Obstetric &Gynaecological Society Meeting, 26 April 2002.
  21. S. Vyjayanthi – “Management of HELLP Syndrome”. XIV Asia Pacific Federation of the International College of Surgeons ,Hyderabad, India, 9 November 2001.
  22. S. Vyjayanthi , Neonatal LCAD & Maternal HELLP Syndrome – A Case Report & Literature Review, North Wales Perinatal Meeting, Wrexham. 28 January 2000