How to Cope Up with Recurrent Failed IVF cycles? By Dr. Vyjayanthi

Repeated IVF Failures, What’s Next?

Whether it’s first or your fourth IVF, a failed fertility treatment cycle is very discouraging. When you are trying to conceive, any cycle that does not lead to pregnancy could feel really bad. But when you have invested emotional energy, time, hopes, and money may very higher, and it’s obvious to experience more frustration after treatment failure. 

An unsuccessful IVF cycle can be emotionally as well as financially devastating. We understand this very well because most of our patients approach us after having at least one failed IVF cycle at other fertility centers. T MotherToBE, we specialize in helping out patients with a tough case of fertility issues. We get clues from the failed cycles for a successful next treatment. 

Our confidence in this particular issue derives from the fact that we have helped the number of couples over the years to conceive, despite their long histories of unsuccessful infertility treatments. 

Here is the success story of a couple overcoming infertility after three consecutive failed treatments. Mrs. Salma and her husband approach us with distress having had three consecutive failed fresh cycles of IVF elsewhere. With this situation, they come to us to know their possible chances of having a baby. 

When couples approach us presenting such a situation, having had one or more repeated IVF failures outside, our initial step would be to do a thorough assessment and examination of both the male and the female partner. This would be helpful to identify the problem lies and we can focus on our unique approach towards the problem.

Solution to Repeated IVF Failure at MotherToBe Fertility Centre in Hyderabad

We at MotherToBe IVF center in Hyderabad, having the expertise and best-in-class technology to help the couples who have recurrent treatment failures. About 40% of the couples who come to us for the IVF treatment have had at least 1 or more IVF failed cycles at other fertility clinics. At MotherToBe fertility center, with expertise and advanced ART procedures, we are capable enough to achieve significant success rates in this group of couples also.

After a complete examination of the candidate, depending upon the current clinical condition we propose further treatment. 

IVF can be modified with a variety of reproductive technologies that are additionally assisted to result in successful outcomes.  

MotherToBe fertility clinic in Hyderabad routinely incorporates innovative procedures in its treatment plans for couples who have experienced multiple IVF failures, including:

• Laser-Assisted Hatching

Assisted hatching is a reproductive technology that helps embryos to attach the womb of the woman,. Pregnancy cannot happen unless the embryo hatches. 

The first group of patients we will offer LAH-laser-assisted hatching would be those who have had more than one failed IVF cycle, previously. The second group of patients, to whom we would be offering this technique, are women with advanced age who present for IVF treatment, specifically having more than 40 years of age. This is also offered for women who have a high FSH. So, these are specific groups of patients to whom we offer laser-assisted hatching intending to obtain better pregnancy rates.

The unfertilized egg is surrounded by a shell known as zona pellucida, where it ensures that only one sperm enters the egg and fertilizes it. After fertilization, the zona pellucida keeps the cells of the embryo together.

In laser-assisted hatching, what we actually do is that the outer shell of the egg, which is called the zona pellucida, is pierced using a laser to creates a small hole and this facilitates the implantation process. 

Another group of patients where we offer LAH is those for whom we do what is called frozen embryo transfer. So, whenever the embryos are frozen due to the vitrification process, the outer shell of the egg could become quite thick. When we thaw the embryos it is important to do the laser-assisted thinning or hatching which facilitates the implantation process and improves the success in this group of patients. At Mother-To-Be fertility center in Hyderabad, we have very high success rates with frozen embryo transfers, close to 70%, by using this additional technology.

Let’s have a look at another latest technology that we have.

• PGS-Pre-Implantation Genetic Screening 

PGS or Pre-implantation genetic screening is offered to a selected group of couples to check whether they are repeatedly producing abnormal embryos which might be one of the reasons the embryos are not able to implant. 

PGS is done for those who have had repeated implantation failure. In this process, we grow embryos in the lab for five days. Later the eggs will be retrieved followed by the stimulation of ovaries and fertilized with the ICSI procedure. 

After that, few cells will be sent for genetic examination, to check for any chromosomal abnormalities in embryo. PGS identifies the chromosomally normal embryos, so these will be implanted in a woman through a frozen embryo transfer process to achieve a healthy pregnancy.

• Blastocyst transfer

Thirdly, we also offer blastocyst transfer what is called extended culture or Day 5 transfer, which again helps to improve the success rate in the group of couples experience recurrent failed IVF cycles.

In the blastocyst process, we advance the culture of embryos for five to six days. At this stage, the embryos have more cells approx-80-100 and start to form 2 distinct layers, here the embryos are then called blastocysts. 

Culturing embryos in the lab for 5-6 days give the embryos better chances to prove their developmental potential.  Unlike embryo transfer, a blastocyst transfer would implant much more quickly. The best embryo will be transferred to the woman which offers the most likely chance of conception. 

MotherToBe is a well-known and referral IVF center in Hyderabad for successful treating couples with multiple failed IVF cycles. With proficiency and advanced assisted reproductive technologies tailored to the patients’ specific conditions, we have developed that confidence and reputation amongst patients. Most patients who approach us after being disheartened with failed IVF cycles outside and have gone back successfully. 

Do you want to discuss your chances of IVF success or any fertility-related issues with us? Please book an appointment or contact us. Book an Appointment